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An unexpected function of a cell-cycle enzyme might explain the toxic effects of its inhibitors

Kaynak Nature 科学Yayınlanma zamanı 28 Eki 2026 08:007 gün önce

İçerik özeti

Nature, Published online: 28 October 2026; doi:10.1038/d41586-026-03288-5

Full Text

Nature, Published online: 28 October 2026; doi:10.1038/d41586-026-03288-5

A previously unknown mechanism required for cells to start proliferating has been identified. A combination of mathematical modelling and cell-based experiments shows that the enzyme WEE1 switches off a protein-degradation complex to allow cell proliferation to start, with implications for WEE1 inhibitors currently in trials for cancer treatments.

Full text provided by the source Nature 科学 via RSS; copyright belongs to the original publisher.

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Orijinal metne git

Ait olduğu kanal: Bilim
Ait olduğu bölge: Küresel bakış
Orijinal dil: English
Kayıt numarası: science-1465a15b

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An unexpected function of a cell-cycle enzyme might explain the toxic effects of its inhibitors · Küresel Panorama