Three people have been killed in a head-on collision between two vehicles on the N2 near Colchester outside Gqeberha in the Eastern Cape.

The crash happened on Sunday and involved vehicles travelling in opposite directions.

Eastern Cape Transport Department spokesperson Unathi Binqose says one vehicle, driven by a man, was travelling towards Makhanda, while the other was carrying two occupants.

All three occupants were declared dead at the scene.

Police have opened a case of culpable homicide and are investigating the cause of the crash.